Substantially expanded in its second edition, Cancer Biology incorporates the important recent advances in research on the cellular and molecular biology of cancer and provides a comprehensive discussion of the mechanisms of carcinogenesis. The text describes the malignant transformation of cells, the invasiveness of cancer cells into host tissues, and the metastatic spread of diseased cells into the host organism. In addition to a new chapter on the biology of tumor metastasis, there are three new chapters on cancer causation, dealing with the chemical and physical carcinogens; viruses and oncogenes; and chromosomal abnormalities and gene depression. Updated material on growth factors and their receptors, differentiation, and the cell matrix is also presented, and the pathophysiology of cancer as a clinical disease is discussed. Praise for the first edition: "Highly recommended for readers who wish to spend several hours with a well-written, well-selected, effectively illustrated, and well-integrated overview of the sciences that join to make up the field of tumor biology."-- The New England Journal of Medicine. "I can think of no better introduction for a graduate student to contemporary cancer research, especially at the cellular level."--G.A. Currie in The Times Higher Education Supplement. "Ruddon provides a status report in a rapidly moving field. The material is will presented and current, and includes excellent essays on differentiation, phenotype expression, genetic mutation, and tumor growth.... A welcome contrast to multiauthor oncologic behemoths that are too heavy to carry and too expensive to acquire."--Journal of the American Medical Association