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Clinical Perspectives in the Management of Down Syndrome. The management of and attitudes toward children and adults with Down syndrome have undergone considerable changes in the course of the condi­ tion's long history (Zellweger, 1977, 1981, Zellweger & Patil, 1987). J. E. D. Esquirol (1838) and E. Seguin (1846) were probably the first physicians to witness the condition without using currently accepted diagnostic designa­ tions. Seguin coined the terms furfuraceus or lowland cretinism in contradis­ tinction to the goiterous cretinism endemic at that time in the Swiss Alps.

The management of and attitudes toward children and adults with Down syndrome have undergone considerable changes in the course of the condi tion's long history (Zellweger, 1977, 1981, Zellweger & Patil, 1987). Seguin (1846) were probably the first physicians to witness the condition without using currently accepted diagnostic designa The management of and attitudes toward children and adults with Down syndrome have undergone considerable changes in the course of the condi tion's long history (Zellweger, 1977, 1981, Zellweger & Patil, 1987).

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by M. Joan Soucek,Susan van Duyne.

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No controlled clinical studies of these medications for Down syndrome have demonstrated their safety and efficacy . Developmental Neuroscience, 33, 414–427.

No controlled clinical studies of these medications for Down syndrome have demonstrated their safety and efficacy, however. Many studies of drugs to treat symptoms of dementia in Down syndrome have included only a few participants. The results of these studies have not shown clear benefits of these drugs, either. 9,10,11 Similarly, studies of antioxidants for dementia in Down syndrome have shown that these supplements are safe, but not effective.