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Download Beta-lactam antibiotics fb2, epub

ISBN: 4762202665
Publisher: Springer (1981)
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-lactam antibiotics (beta-lactam antibiotics) are the antibiotic agents that contain a beta-lactam ring in their molecular structure.

-lactam antibiotics (beta-lactam antibiotics) are the antibiotic agents that contain a beta-lactam ring in their molecular structure. This includes penicillin derivatives (penams), cephalosporins (cephems), monobactams, carbapenems and carbacephems. Most β-lactam antibiotics work by inhibiting cell wall biosynthesis in the bacterial organism and are the most widely used group of antibiotics

This interferes with osmotic stability of the bacteria.

This interferes with osmotic stability of the bacteria. Different β-lactam antibiotics inhibit different PBPs and have varying efficacies in inhibiting bacterial growth or killing the organism.

Beta-lactam antibiotics are spread mostly in the extracellular space. The penetration across biological barriers is limited; sometimes it can be reversed with higher dosing. Intracellular penetration of beta-lactam is poor

Beta-lactam antibiotics are spread mostly in the extracellular space. Intracellular penetration of beta-lactam is poor. The vast majority of beta lactam antibiotics are excreted through the kidneys but exceptions do exist (oxacillin, cefoperazone, ceftriaxone). The half-life of beta-lactam antibiotics is rather short and varies from a half an hour (penicillin, oxacillin, cephalotin) to 2-2, 5 hours. An exceptional long half time has ceftriaxone (8 hr. allowing once daily administration

Beta-lactam antibiotics are the largest family of antimicrobial agents and the most widely used in current clinical practice

Beta-lactam antibiotics are the largest family of antimicrobial agents and the most widely used in current clinical practice.

-lactam antibiotics are a broad class of antibiotics which include penicillin derivatives, cephalosporins, monobactams, carbapenems and β-lactamase inhibitors.

-lactam antibiotics are a broad class of antibiotics which include penicillin derivatives, cephalosporins, monobactams, carbapenems and β-lactamase inhibitors; basically any antibiotic agent which contains a β-lactam nucleus in its molecular structure. -lactam antibiotics are indicated for the prophylaxis and treatment of bacterial infections caused by susceptible organisms.

Beta-lactam antibiotics represent the oldest class of antibiotics used in the treatment of infections. Consequently, a large number of agents have been developed. Some are absorbed from the gastrointestinal tract. The serum half-life (t1/2) of most beta-lactams is 1-2 hours. Ceftazidime and temocillin are more long-lasting with a t1/2 of 4-6 hours and ceftriaxone of 8-10 h. These values relate to patients with normal renal function.

BETA-LACTAM ANTIBIOTICS Basic characteristics: They are bactericidal drugs. They inhibit building of bacterial cell wall by interference with the synthesis of peptidoglycan. The bacterial enzymes that are affected by beta-lactams are called penicilinbinding proteins (PBPs). There are various PBPs differing in their detail function, quantity, and affinity for betalactams. Principally, the effect of beta-lactams is mostly expressed against multiplying bacteria that are building their cell wall intensively.

Beta-lactam antibiotic - β lactam antibiotics are a broad class of antibiotics that include penicillin derivatives, cephalosporins, monobactams, carbapenems, and β lactamase inhibitors, that i. .

Beta-lactam antibiotics. Penicillins Cephalosporins Carbapenems Monobactams

Beta-lactam antibiotics. Penicillins Cephalosporins Carbapenems Monobactams. I. General principles of antibiotic activity: Anti-bacterial drugs have selective toxicity, that is they interact with a target present on the bacterial cell, the prokaryote, that is not present in the mammalian host, the eukaryote. 1- What are the targets for the ß-lactam antibiotics? Although the discovery of penicillin by Alexander Fleming was serendipitous (he noticed a mold, the penicillium mold, killing the staphylococci he was growing on an agar plate), there has since been a tremendous effort to understand exactly how penicillins and related compounds actually KILL bacteria.

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